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It significantly decreased levels of malondialdehyde (MDA), a marker of oxidative damage, while downregulating the expression of transient receptor potential vanilloid 1 (TRPV1), NF-κB, COX-2, and the pro-apoptotic protein Bax

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Recently, scores based on indirect biomarkers of endotheliopathy, such as EASIX or modified EASIX, have demonstrated to be reliable tools to predict the incidence or severe CRS and/or ICANS and their related decrease of the progression-free survival (204–207)