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These effects are largely mediated by altered renal hemodynamics and dysregulation of hormonal pathways such as the renin-angiotensin-aldosterone system (RAAS) (Ricardo et al., 2017

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However, preclinical studies have demonstrated more promising effects of NAC, including improved systemic and hepatic lipid metabolism, reduced inflammation-induced liver damage, and enhanced glucose tolerance in NAFLD-induced mice, likely due to its role in restoring hepatic glutathione and glutathione reductase levels