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Bone marrow stromal cells dictate lanosterol biosynthesis and ferroptosis of multiple myeloma | Oncogene

(63) demonstrated that the DIO2 Thr92Ala polymorphism substantially reduces type 2 deiodinase activity, impairs local T4-to-T3 conversion, and is associated with lower serum T3 levels in patients treated with levothyroxine

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Note that current mechanistic understanding as referenced here is derived primarily from biochemical assays, cell-culture studies, and animal models