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What is the MTHFR Mutation?
While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control
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The larger the reserves, the greater the normal daily losses, and vice versa: the smaller the pool (reservoir) of cobalamins, the less B12 will be eliminated, which could be the result of a metabolic adaptation to low reserves
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