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additionally, GPX4 can inhibits the phospholipid peroxidation of adipocytes, although the specific mechanism is unclear ( −/− AT mice, and spontaneously produced impaired insulin signaling in the liver, resulting in systemic inflammation and disorders of glucose metabolism ( FSP1 Ferroptosis-suppressor-protein 1 (FSP1) is a recently discovered non-GPX4-dependent ferroptosis inhibitory factor, which exhibits a different pathway of action from GPX4 in the process of ferroptosis inhibition, mainly regulated by the NAD (P)H/FSP1/CoQ10 system ( Figure 1C )