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Involvement of Oxidative Stress, Inflammation, and Glutamate in Ototoxicity, and their Attenuation by Simultaneous Activation of Nrf2 and Elevation of Antioxidant Compounds
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In vivo , treatment of AR mice with kaempferol reduced spleen weight, IgE, and histamine levels in serum, reduced IL-4, and increased IFN-ϒ levels in spleen tissue in nasal mucosa treated with kaempferol reduced IL-32, thymic stromal lymphopoietin (TLSP) expression, and MIP-2, ICAM-1 and Cox-2 levels (Oh et al., 2013)
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