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Concordant clinical presentation, suggestive neuroimaging findings, and/or biochemical evidence raise suspicion for the correct diagnosis, but acute neurologic conditions consistent with vitamin B12 deficiency should be treated without waiting for definitive biochemical confirmation (69)

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However, therapeutic doses for treating deficiency range from high-dose oral supplements (1,000–2,000 µg daily) to intramuscular injections of 1 mg, particularly for pernicious anaemia or malabsorption conditions