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besides, its first metabolite cotinine also did not influence the osteogenic differentiation of SCP-1 cells
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For example, in the skeletal system, spermidine (SPD) could specifically reverse excess iron-induced metabolic imbalance and differentiation inhibition in osteoblasts (MC3T3-E1) and osteoclasts (RAW264.7) via SIRT1/SOD2 activation, reducing the bone loss of aged rats
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