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While physical, chemical, and biological stimuli each offer unique advantages in triggering specific functional responses, the complexity of oral pathological microenvironments often involves multiple overlapping cues

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55 , 56 GJCs formed by Cx43 and Cx30 between astrocytes form an astrocyte network to transfer or exchange small molecules and ions, such as glucose, amino acids, ATP, and Ca 2+ , which are essential for astrocytic function