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Since this discovery, aryloxy phosphonamidate prodrugs have come to be known as the ‘ProTide’ (pro-nucleotide) [94] technology and have resulted in two US FDA-approved drugs: tenofovir alafenamide for the treatment of HIV (ProTide of PMPA) [81] and sofosbuvir for the treatment of Hepatitis C (Figure 11) [95]
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