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Concerning the NF-κB pathway, ER inhibited IκB-α degradation and p65 nuclear translocation, suppressed NF-κB DNA binding/transcriptional activity causing decreased expression of TNF-α, IL-6, IL-1β, iNOS, and COX-2, as well as activity of iNOS and COX-2 [192]

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In practice, no one has tested the combination in people, so you’re stacking two separate research stories and hoping they add up