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H3K9me3 can be synthesized by three histone methyltransferases: SET domain bifurcated-1 (SETDB1) and suppressor of variegation 3โ9 homologs 1 and 2 (SUV39H1/2) (OโCarroll et al., 2000
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These principles are implemented in EU projects (e.g., NANoREG, NanoReg2, SUN, caLIBRAte) that integrate risk pre-assessment, modeling (QSAR, AOP pathways), iterative stakeholder engagement, and green synthesis to align early-stage innovation with safety and regulatory preparedness (Kraegeloh et al., 2018
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