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Based on the basic neuroscience data, we tried a combined open label treatment to bolster prefrontal function: the α2A-adrenoceptor agonist, guanfacine, which strengthens prefrontal connectivity, and the anti-oxidant, N- acetylcysteine (NAC), which protects mitochondria and reduces kynurenic acid blockade of NMDA receptors

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For example, quercetin and luteolin act as metal ion chelators, binding Fe²⁺ and Cu²⁺, which catalyze ROS production, thereby reducing oxidative stress within melanocytes 141