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A 2026 review in the Journal of the American Academy of Orthopaedic Surgeons Global Research and Reviews, by Rahman, Lee, and Seeds, categorised both BPC-157 and TB-500 as wound-healing peptides that promote angiogenesis, integrin-mediated extracellular matrix remodelling, and fibroblast activation, while concluding that there is a current lack of clinical trials for either compound in orthopaedic settings [1]
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