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10.1038/sj.cdd.4402285 [DOI] [PubMed] [Google Scholar] Mucida D., Park Y., Kim G., Turovskaya O., Scott I., Kronenberg M., and Cheroutre H

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Given the strong link between osteoporosis and oxidative stress, it was found that CUR not only has antioxidant and anti-inflammatory effects but also attenuates oxidative stress and promotes bone formation by modulating the MDA/GSH ratio, as demonstrated by the mouse OVX model ( In addition, CUR reduced the intranuclear expression of NF-κB p65 by inhibiting the phosphorylation of IκBα and its degradation, thereby inhibiting NF-κB activation, which plays a key role in the inhibition of osteoclast genesis in rheumatoid arthritis patients