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baculatum enzyme [66], but present in more oxidized forms [68], and the enzyme from Desulfovibrio vulgaris (Hildenborough) [75] where it is absent even in oxidized forms, and heterogeneity in the positions of the Ni center and the − SeCys ligand [74, 75, 77]
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Bidirectional nutrient manipulation A recurring feature of these feedback circuits is bidirectional nutrient manipulation, whereby cancer cells not only consume but actively reprogram surrounding stromal and immune cells to supply essential metabolites
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