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In the context of cancer immunotherapy, HDACi not only exert direct antitumor effects on cancer cells but also enhance the activation of immune cells such as T cells and NK cells within the TME, thereby improving antitumor responses and patient survival (Pan and Zheng, 2020)
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Sustained reduction of caloric intake results in reduced adiposity and weight, even though adaptive reduction in energy expenditure partially attenuates the pace of weight loss (136)
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