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IGF-1 LR3 also binds the insulin receptor and IGF-1R/IR hybrid receptors with lower affinity, so assays that need a clean IGF-1R readout use IGF-1R-selective inhibitors or knockdown as controls

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Nucleosomal Histone Peptides Endogenous peptide epitopes of histones from nucleosomes induce immune tolerance and promote CD4 + and CD8 + T reg responses, and reduce lupus nephritis and B cell activation in (SWR x NZB) F1 (SNF1) mice, [70, 71, 72] also blocking pathogenic autoimmunity in human SLE