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MK-677 Key Research Findings Nitrogen Balance Reversal (1998, Healthy Men) Research Focus : Whether oral MK-677 could reverse diet-induced protein catabolism in healthy men Key Results : Nitrogen balance shifted from -2.67 g/day to +0.31 g/day in the MK-677 group versus -1.48 g/day in placebo (P less than 0.01)

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The findings of this study, which indicate a link between SF IL-18 levels and osteophyte severity in end-stage knee OA patients with varus alignment, could contribute to the development of future OA treatment strategies