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Activation of the PI3K/AKT pathway primarily drives synapse formation and density increases, while MAPK/ERK pathway activation predominantly influences dendritic growth and arborization
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The damage appears to be upstream, at the level of the hypothalamic signal that starts the pulse (Priem, Shanley and Malan, Metabolism 1976, showing that prior consumption of ethanol attenuates the normal growth hormone response and proposing depletion of hypothalamic catecholamine stores as the mechanism)
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