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In vivo experiments in mice highlighted that the transplantation of osteosarcoma cells stably overexpressing miR-26a, suppressed tumor growth ( As reported in the following lines, it is noteworthy that the majority of the studies available in the Literature concerning miRNAs, the GH/IGF1 axis and the IGF system in osteosarcoma are focused on miRNAs that target, both directly or indirectly, the IGF1R both in vivo and in vitro