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Instead, wastes egress by diffusion from the ISF to the arterial PVS and then towards the pial surface, vasomotion and arterial pulsations facilitate CSF-ISF mixing in the PVS of penetrating arteries, thereby enhancing ISF–CSF exchange and the diffusion gradient for waste clearance is created by CSF bulk flow along the large pial arteries on the brain surface (114, 117, 118)
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The establishment of industry alliances or public databases should be promoted to address the issue of data silos
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