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Main Hormonal Regulators of Somatotrophs—GHRH and Somatostatin Two brain (hypothalamus)–derived modulating factors, the stimulator GHRH and the inhibitor somatostatin (70), act as the primary central regulators of both synthesis and secretion of pituitary GH ( Figure 1 ) (1, 7, 14, 15, 20, 21, 26, 34, 38)

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Intramuscular injections may feel slightly more noticeable since the needle goes deeper into the muscle, but using proper technique and following your provider’s instructions can make the process more comfortable