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The first site-specific succinylation-modified histones were obtained using thiol-ene addition at the H2BK34 site, and a smFRET study showed that the modification greatly attenuated DNA–histone interactions and reduced nucleosome structural stability ( in vitro and enrichments in promoters of active genes in vivo (Zorro Shahidian et al., 2021)
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157 More typically, the acidic pH of gastric juices can promote conjugated linoleic and conjugated linolenic acid reactions with dietary nitrite (NO 2 – ) to form bioactive nitro lipids in vivo
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