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[ 30 ] Heme triggers BACH1 degradation through the ubiquitinβproteasome pathway by promoting its interaction with the ubiquitin E3 ligase adaptor proteins Fβbox protein 22 (FBXO22, a cullinβRING ligase 1 (CRL1) substrate receptor), and the activated NRF2 induces HOβ1 expression, thus represses the FBXO22βdependent degradation of BACH1 in lung cancer cells
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(London, United Kingdom: Elsevier: Academic Press), 199β215
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