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SP and HK-1 generated from macrophages, bronchial cells and mast cells cause degranulation of human mast cells via MRGPRX2, Mas-related G protein-coupled receptor-X2, which is upregulated in the lung mast cells and serum of asthmatic patients [122]

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For those with PSC without IBD, CRC screening is recommended every 5 years with colonoscopy or sooner if there is clinical suspicion for interval development of IBD