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Magnetic resonance imaging (MRI) and histological analysis have also detected increased iron levels in both the white and gray matter of MS patients’ brains, with iron accumulation found in the white matter and macrophages of the basal ganglia (Dusek et al., 2016)

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Pharmacological competitive inhibitors of HO activity such as the heme analogs SnPPIX or ZnPPIX (Kato et al., +/− mice lead to significant worsening of IRI outcomes (Tsuchihashi et al., 2006)