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The role of off-therapy viral kinetics in the timing and severity of flares in hepatitis B e antigen-negative patients
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To investigate whether one or both putative binding sites were functional, we cloned fragments of 98 and 96 bp of the human IGF-1 3′ UTR mRNA (NM_ 000618) containing the two putative miRNA-binding sites into the psiCHEK-2 vector (Supplementary Fig
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