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Among the other residues predicted to interact with EAR-20, Ser773 of GluN1 exhibited the highest number of contacts, forming four distinct interactions within the binding pocket

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While no significant changes were observed in cytokine levels (IL-2, IL-6, IL-8, IL-10, IL-1α, IFN-γ, TNF-α, VEGF, and MCP1), the Ginkgo Synergy plus choline group exhibited a significant reduction (57%) in epidermal growth factor (EGF), a protein that is often overexpressed in individuals with mild cognitive impairment or Alzheimer’s disease (173)