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ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation - ScienceDirect

The only way to be sure that Se status was low before disease occurs is to measure erythrocyte Se which, with a half-life of 120 d, will only vary after a longer period of inflammation (Reference Stefanowicz, Talwar and O'Reilly46)

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2.10.1 Limitation of in-vitro model Despite their value in mechanistic research, in vitro models present several critical limitations that constrain their translational applicability (Slanzi et al., 2020)