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Concurrently, the antioxidative response, i.e., the biosynthesis of GSH, was interrupted by HSV-1, as evidenced by the findings that both the GSH level and the GSH/GSSG ratio were decreased along with increases in ROS production, lipid peroxidation, and cell death in HSV-1-infected cells

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PD is characterised by a progressive loss of, primarily, dopaminergic neurons of the substantia nigra that project to the striatum, resulting in its motor symptoms of bradykinesia, rigidity and tremor