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This phenomenon of signal crosstalk has been reviewed by Zhou et al., highlighting the complex interactions between the Wnt/β-catenin pathway activation and immune exclusion ( On the other hand, GC excess has been demonstrated to be strongly associated with depletion of T cell subtypes in ACC, both at the mRNA (56) and protein expression levels ( However, while we observed a direct association between CTNNB1 and CD3 + immune cells, LEF-1 was not linked to any of the immune cell subtypes but interestingly associated with impaired expression of antigen presentation in tumours suggesting modulation of immune recognition

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