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This persistent inflammation constitutes a key pathogenic factor in the progression of T2DM, further impairing insulin signaling and compromising carbohydrate metabolism ( Several studies have associated T2DM with periodontitis, suggesting a bidirectional association between both pathologies (Santos et al., 2015
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Transforming growth factor-β (TGF-β) signaling plays a vital role in regulating cell growth, differentiation and development in a variety of biological systems
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