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In fibrotic stages, Gyps reduces carbon tetrachloride (CCl 4 )-induced collagen deposition and hydroxyproline content (Liu et al., 2023b), with gypenoside XLVI demonstrating antifibrotic efficacy in acute/chronic liver injury models (Li et al., 2023c)

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Trial completion rate 💡 No participants withdrew due to adverse effects in the major trials 💡 Both oral doses (250mg and 1000mg) were well tolerated Intravenous glutathione is not FDA-approved for any indication The use of GSH IV for skin lightening raises safety concerns The long-term safety of high-dose oral GSH is not fully established Safety data during pregnancy/breastfeeding is limited Researcher's notes •Oral supplementation has an excellent safety record in trials •No serious adverse events were reported with oral GSH